Regulation of Chromosome Segregation and Its Exploitation on Phenotypic Cancer Drug Screen

Abstract:

Precise orchestration of chromosome segregation during mitotic cell division is vital to keep genetic stability of eukaryotic cells and mitotic kinases such as cyclin dependent kinase-1, aurora kinases, or spindle assembly checkpoint kinases, play key roles in this process.  Because of their vital roles in mitotic progression, mitotic kinases are often exploited as the chemotherapeutic targets of cancer. In the talk, the principle components of the mitotic machinery and their coordination by spindle assembly checkpoint kinases such as monopolar spindle kinase-1 will be discussed in a molecular detail. Additionally, the conceptual application of a high-content image-based analysis on cancer drug screening, an interdisciplinary study to fight the cancer, will be discussed.

NYU Shanghai STEM seminar series is a weekly seminar series on every Wednesday, starting from 12th October 2016. 
Please see below tentative schedule of STEM seminar series in 2017 Spring Semester.

• Feb. 8: NO SEMINAR
• Feb. 15: Li Li, Associate Professor of Neural Science and Psychology
• Feb. 22: Xiao-Jing Wang, Global Professor of Neural Science  
• Mar. 1: Hanghui Chen, Assistant Professor of Physics
• Mar. 8: Vladas Sidoravicius, Professor of Mathematics
• Mar. 15: Keith Ross, Professor of Engineering and Computer Science
• Mar. 22: Olivier Marin, Associate Professor of Computer Science
• Mar. 29: Xinying Cai, Assistant Professor of Neural and Cognitive Sciences
• Apr. 5: Spring Recess, NO SEMINAR
• Apr. 12: Jungseog Kong, Assistant Professor of Biology
• Apr. 19: Gang Fang, Assistant Professor of Biology
• Apr. 26: Pierre Michael Tarres, Visiting Professor of Mathematics
• May 3: Jeff Erlich, Assistant Professor of Neural and Cognitive Sciences
• May 10: Laurent Mertz, Visiting Assistant Professor of Mathematics
• May 17: NO SEMINAR