Abstract:
Improving enzyme activity is important for its industrial application. Our group focus on developing the following computational strategies in enzyme engineering: 1, Modification of the enzyme’s entrance/leaving tunnel: we used CatA, MAO-N, FDH as examples. Also we applied SASMD to find key residues in the enzyme tunnel. 2, Catalytic site design: we constructed a catalytic site design server based on ROSETTA. We hope that our tools can help experimental group in enzyme design.
Biography:
Jianping Lin received a B.S. in Chemistry from Beijing University in 1997, a M.S. in Chemistry from Beijing University in 2000, and a Ph.D. in Chemistry from Duke University in 2005. He did his postdoctoral research at the Beckman Institute in City of Hope medical center before joining the faculty of College of Pharmacy, Nankai University in 2009. He is currently Professor in the College of Pharmacy. His research focuses on simulation and design of biomaterials, computer-aided drug design and enzyme design. He published more than 30 papers in journals: Science, Angewandte Chemie, Chemical Science, Journal of Cheminfomatics, PCCP etc.
Seminar Series by the NYU-ECNU Center for Computational Chemistry at NYU Shanghai