Order from Disordered Bladder Cancer Mutations

Topic: 
Order from Disordered Bladder Cancer Mutations: Analysis of Driver Gene Mutual Exclusivity among Individuals and Races
Date & Time: 
Wednesday, March 28, 2018 - 16:30 to 17:30
Speaker: 
Gang Fang, Assistant Professor of Biology
Location: 
Room 204, NYU Shanghai | 1555 Century Avenue, Pudong New Area, Shanghai

Abstract:

Genomic factors contribute to racial and ethnic group disparities in cancer risk, development and treatment. It remains yet unclear how cancer driver genes attribute to such disparities in Urothelial Bladder Carcinoma (BLCA). In this report, we sequenced exomes of 17 Chinese BLCA patients. Combining our data with over 400 BLCA somatic mutations downloaded from TCGA and ICGC, we made cross analysis of cancer driver gene among individuals and racial groups. We found two cancer genes SMAD4 and TRPM3 that are more linked to bladder cancer in Chinese population. BLCA somatic mutational heterogeneity is pervasive in all ethnic groups, which is in line with most other type of cancers. However, given the over 400 highly personalized gene mutation profiles, we found significant discordance between Asian and Caucasian populations in their BLCA driver genes. Using gene mutual exclusivity, we concluded that the Ras-Raf-MAPK pathway is related to this racial-scale driver gene discordance. Asian bladder cancer patients have a higher chance to have mutations in the Ras-Raf-MAPK pathway. We also suggest, as cancer patient cohort grows, it is feasible and important to focus on biological relationship between gene clusters or pathways, instead of single genes, in the study of mechanisms leading to the birth and development of cancer.

 

*Please note that tea and coffee reception will start at 4:00 PM.  

NYU Shanghai STEM Seminar Series - Spring 2018
4:30-5:30 PM, Every Wednesday | Room 204, NYU Shanghai

  • March 21: Jeffrey Erlich, Assistant Professor of Neural and Cognitive Sciences
  • March 28: Gang Fang, Assistant Professor of Biology
  • April 11: Tao Huang, Visiting Assistant Professor of Mathematics
  • April 18: Li Li, Associate Professor of Neural Science and Psychology
  • April 25: Leonardo T. Rolla, Visiting Assistant Professor of Mathematics
  • May 02: Xinying Cai, Assistant Professor of Neural and Cognitive Sciences
  • May 09: Hanghui Chen, Assistant Professor of Physics

This event is for NYU Shanghai community. External atteendees please RSVP HERE.