Professor Tamar Schlick’s Research on RNA Modeling Published in PNAS

Center member and NYU Professor of Chemistry, Mathematics, and Computer Science Tamar Schlick’s new RNA viral research has been published in the esteemed journal Proceedings of the National Academy of Sciences and featured in the PNAS showcase on Kudos. The modeling study combining graph theory, evolutionary relationships, and biophysics shows how the frameshifting element structure of SARS-CoV-2, the viral agent of Covid-19, evolved among coronaviruses by mutations. It further suggests targeted mutations to alter the RNA structure with the intention to alter viral infectivity. Such information provides insights into new RNA- editing strategies for anti-viral therapeutics against a broad range of viruses.

Journal Reference:

Yan, S., Zhu, Q., Hohl J., Dong, A., and Schlick, T.Evolution of Coronavirus Frameshifting Elements: Competing Stem Networks Explain Conservation and VariabilityProc. Nat. Acad. Sci., 120 (20) e2221324120 (2023)

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