In this seminar, I will talk about the structural basis and catalytic mechanism of several enzymes in microbial catalysis and natural product biosynthesis. We determined the crystal structure (especially the enzyme-ligand complex structure) and conducted computational calculations. The results were merged for mechanistic studies and engineering guidance.
Jiahai Zhou is Professor of State Key Laboratory of Bio-organic Chemistry and Natural Products, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. He received his Ph.D. from Shanghai Institute of Organic Chemistry, CAS in 2000, and did postdoctoral research at University of Michigan during 2001-2006. The research in Zhou laboratory is mainly focused on the structural mechanism and protein engineering of key enzymes in biocatalysis and biosynthesis. Their approaches include a variety of biochemical and biophysical methods, particularly the high-resolution x-ray crystallography and molecular dynamics.